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KMID : 0370220010450060724
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Yakhak Hoeji
2001 Volume.45 No. 6 p.724 ~ p.729
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Effects of Ethyl Acetate Extract from Ulmus davidiana var. japonica on Melanogenesis
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천현자/Chun HJ
정승일/김일광/Jeong SI/Kim IK
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Abstract
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Melanogenesis is a physiological process resulted in the synthesis of melanin pigments, which has a role in protecting skin from the damaging effect of ultra-violet (UV) radiation. The main aim of the present study was to examine the effect of Ulmus davidiana var. japonica (UL) on melanogenesis. Cells were cultured in the presence of various concentrations of Ulmus davidiana var. japonica. For 48 h, and there were estimated total melanin contents as a final product and activity of tyrosinase, a key enzyme, in melanogenesis. Among the four solvent extracts tested, EtOAc extract mostly increased tyrosinase activity And EtOAc extract increased the melanin contents and tyrosinase activity in a dose-dependent manner. Especially, It was observed that 100㎍/ml/ EtOAc extract promotes melanin secretion in B16/F10 melanoma cells by 140% at 48 h treatment and activity of tyrosinase increased by 180% in the presence of same concentration. In conclusion, as for EtOAc extract treatment, there was no effect on the viability of B16/F10 cell, only to stimulate melanization.
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KEYWORD
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